Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.T256R

c.767C>G

Surrounding Variants

21 papers

NM_000546.6

p.T256I

c.767C>T

9 papers

NM_000546.6

p.T256insFs

c.766dupA

2 papers

NM_000546.6

p.T256insFs

c.766_767insAA

14 papers

NM_000546.6

p.T256K

c.767C>A

4 papers

NM_000546.6

p.T256delFs

c.766delT

67 papers

NM_000546.6

p.I255del1

c.763_764delGAT

1 paper

NM_000546.6

p.I251_I255del5

c.751_764del15

1 paper

NM_000546.6

p.S240_T256delFs

c.720_766del47

4 papers

NM_000546.6

p.T256S

c.766A>T

3 papers

NM_000546.6

p.T256T

c.768A>T

19 papers

NM_000546.6

p.T256A

c.766A>G

7 papers

NM_000546.6

p.T256T

c.768A>G