Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

19 papers

NM_000546.6

p.T256A

c.766A>G

Surrounding Variants

4 papers

NM_000546.6

p.T256S

c.766A>T

31 papers

NM_000546.6

p.T256P

c.766A>C

1 paper

NM_000546.6

p.T256insFs

c.766_767insTA

1 paper

NM_000546.6

p.I255delFs

c.765delG

1 paper

NM_000546.6

p.T253_I255delFs

c.758_764del7

1 paper

NM_000546.6

p.L252_I255del4

c.754_764del12

1 paper

NM_000546.6

p.I251_T256Fs

c.751_766delinsCTCCTFs

20 papers

NM_000546.6

p.T256fs

c.766_767fs

21 papers

NM_000546.6

p.T256I

c.767C>T

2 papers

NM_000546.6

p.I255I

c.765C>T

NM_001126118.2

p.I216I

c.648C>T

9 papers

NM_000546.6

p.T256R

c.767C>G

8 papers

NM_000546.6

p.I255M

c.765C>G