Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I255delFs

c.763delT

Surrounding Variants

1 paper

NM_000546.6

p.I255insFs

c.763dupA

69 papers

NM_000546.6

p.I255S

c.764T>G

65 papers

NM_000546.6

p.I255T

c.764T>C

52 papers

NM_000546.6

p.I255N

c.764T>A

1 paper

NM_000546.6

p.T253_I254del2

c.757_761del6

1 paper

NM_000546.6

p.L252_I255delFs

c.754_763del10

1 paper

NM_000546.6

p.S240_I254del15

c.718_761del45

2 papers

NM_000546.6

p.I255I

c.765C>T

NM_001126118.2

p.I216I

c.648C>T

8 papers

NM_000546.6

p.I255M

c.765C>G

4 papers

NM_000546.6

p.I255insFs

c.764dupT

1 paper

NM_000546.6

p.I255insFs

c.764_765insTT

8 papers

NM_000546.6

p.I255fs

c.763_764fs