Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

117 papers

NM_000546.6

p.I255F

c.763A>T

Surrounding Variants

4 papers

NM_000546.6

p.I255fs

c.763_764fs

8 papers

NM_000546.6

p.I255V

c.763A>G

4 papers

NM_000546.6

p.I255L

c.763A>C

1 paper

NM_000546.6

p.I254insFs

c.762dupC

1 paper

NM_000546.6

p.L252_I254ins1

c.754_762dup9

1 paper

NM_000546.6

p.I255_T256insC

c.763_767ins3

1 paper

NM_000546.6

p.I255_T256insCA

c.763_767ins6

1 paper

NM_000546.6

p.I255_T256ins4

c.763_767ins12

1 paper

NM_000546.6

p.I254delFs

c.762delG

17 papers

NM_000546.6

p.L252_I254del0

c.754_762del9

1 paper

NM_000546.6

p.I251_I254delFs

c.753_762del10

1 paper

NM_000546.6

p.I255insFs

c.763dupA