Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T253_I254del1

c.758_760delTGG

Surrounding Variants

1 paper

NM_000546.6

p.T253_I254ins0

c.758_760dupCCA

52 papers

NM_000546.6

p.I254S

c.761T>G

47 papers

NM_000546.6

p.I254T

c.761T>C

47 papers

NM_000546.6

p.I254N

c.761T>A

1 paper

NM_000546.6

p.I254delFs

c.760delT

2 papers

NM_000546.6

p.R249_I254del0

c.746_760del15

1 paper

NM_000546.6

p.N247_T253del7

c.739_758del21

4 papers

NM_000546.6

p.I254I

c.762C>T

7 papers

NM_000546.6

p.I254M

c.762C>G

8 papers

NM_000546.6

p.I254fs

c.760_761fs

1 paper

NM_000546.6

p.I254delFs

c.760_761delAT

4 papers

NM_000546.6

p.I254fs

c.760_761fs