Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_000546.6

p.I254fs

c.760_761fs

Surrounding Variants

15 papers

NM_000546.6

p.I254F

c.760A>T

33 papers

NM_000546.6

p.I254V

c.760A>G

12 papers

NM_000546.6

p.I254L

c.760A>C

2 papers

NM_000546.6

p.T253insFs

c.758dupC

1 paper

NM_000546.6

p.T253_I254ins1

c.759_760insCTC

2 papers

NM_000546.6

p.I254_I255insT

c.760_764ins3

1 paper

NM_000546.6

p.I254_I255insCA

c.760_764ins6

1 paper

NM_000546.6

p.I254_I255insLTI

c.760_764ins9

5 papers

NM_000546.6

p.T253delFs

c.759delG

1 paper

NM_000546.6

p.P250_T253delFs

c.748_758del11

1 paper

NM_000546.6

p.P250_T253del0

c.748_759del12

1 paper

NM_000546.6

p.T253_I254ins0

c.758_760dupCCA