Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_000546.6

p.T253I

c.758C>T

Surrounding Variants

11 papers

NM_000546.6

p.T253S

c.758C>G

1 paper

NM_000546.6

p.T253insFs

c.758_759insG

12 papers

NM_000546.6

p.T253insFs

c.757dupA

20 papers

NM_000546.6

p.T253N

c.758C>A

1 paper

NM_000546.6

p.T253delFs

c.757delT

1 paper

NM_000546.6

p.L252_T253del1

c.755_757delTGA

2 papers

NM_000546.6

p.I251_L252del2

c.751_755del6

1 paper

NM_000546.6

p.I251_T253delFs

c.751_757del7

1 paper

NM_000546.6

p.M246_T253del0

c.737_757del21

1 paper

NM_000546.6

p.T253T

c.759C>T

1 paper

NM_000546.6

p.T253insFs

c.757_758dupAC

11 papers

NM_000546.6

p.T253fs

c.757_758fs