Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L252delins

c.755_756delinsCA

Surrounding Variants

1 paper

NM_000546.6

p.L252insFs

c.755dupT

11 papers

NM_000546.6

p.L252fs

c.754_755fs

1 paper

NM_000546.6

p.L252L

c.756C>A

2 papers

NM_000546.6

p.L252delFs

c.755delA

1 paper

NM_000546.6

p.L252Fs

c.754_756delinsTFs

1 paper

NM_000546.6

p.R249_L252delFs

c.746_755del10

1 paper

NM_000546.6

p.L252insFs

c.754dupC

1 paper

NM_000546.6

p.P250_L252insFs

c.750_754dup5

4 papers

NM_000546.6

p.L252R

c.755T>G

67 papers

NM_000546.6

p.L252P

c.755T>C

7 papers

NM_000546.6

p.L252H

c.755T>A

11 papers

NM_000546.6

p.L252delFs

c.754delG