Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.I251I

c.753C>T

Surrounding Variants

16 papers

NM_000546.6

p.I251M

c.753C>G

2 papers

NM_000546.6

p.I251ins1

c.752_753insTAT

1 paper

NM_000546.6

p.I251_L252insFs

c.753_754insGT

10 papers

NM_000546.6

p.I251fs

c.751_752fs

1 paper

NM_000546.6

p.I251delins

c.752_753delinsAT

1 paper

NM_000546.6

p.I251delFs

c.752delA

1 paper

NM_000546.6

p.I251delFs

c.751_752delAT

1 paper

NM_000546.6

p.N247_I251delFs

c.739_752del14

1 paper

NM_000546.6

p.M246_I251del0

c.738_752del15

1 paper

NM_000546.6

p.S241_I251delFs

c.721_752del32

1 paper

NM_000546.6

p.I251insFs

c.751dupA

1 paper

NM_000546.6

p.R249_I251insFs

c.747_751dup5