Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P250P

c.750C>A

Surrounding Variants

1 paper

NM_000546.6

p.P250P

c.750C>T

6 papers

NM_000546.6

p.P250fs

c.748_749fs

2 papers

NM_000546.6

p.P250delins

c.749_750delinsTT

1 paper

NM_000546.6

p.R249_P250delFs

c.746_749del4

1 paper

NM_000546.6

p.N247_P250delins

c.741_750delinsA

1 paper

NM_000546.6

p.N247_P250delFs

c.740_749del10

1 paper

NM_000546.6

p.G245_P250delFs

c.733_749del17

182 papers

NM_000546.6

p.P250L

c.749C>T

7 papers

NM_000546.6

p.P250R

c.749C>G

6 papers

NM_000546.6

p.P250H

c.749C>A

21 papers

NM_000546.6

p.I251fs

c.751_752fs

1 paper

NM_000546.6

p.P250delins

c.748_749delinsTT