Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.N247K

c.741C>A

Surrounding Variants

12 papers

NM_000546.6

p.N247N

c.741C>T

9 papers

NM_000546.6

p.N247K

c.741C>G

3 papers

NM_000546.6

p.N247fs

c.739_740fs

2 papers

NM_000546.6

p.N247_R248insFs

c.741_742insA

1 paper

NM_000546.6

p.N247insFs

c.740_741ins5

2 papers

NM_000546.6

p.M246_N247delFs

c.737_740del4

1 paper

NM_000546.6

p.G244_N247delFs

c.730_740del11

2 papers

NM_000546.6

p.M243_N247del0

c.729_740del12

9 papers

NM_000546.6

p.R248fs

c.742_743fs

2232 papers

NM_000546.6

p.R248W

c.742C>T

NM_001276697.3

p.R89W

c.265C>T

176 papers

NM_000546.6

p.R248G

c.742C>G

1 paper

NM_000546.6

p.R248insFs

c.742_743insGG