Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

149 papers

NM_000546.6

p.M246I

c.738G>C

Surrounding Variants

146 papers

NM_000546.6

p.M246I

c.738G>T

1 paper

NM_000546.6

p.M246_N247insFs

c.738_739ins13

4 papers

NM_000546.6

p.M246fs

c.736_737fs

148 papers

NM_000546.6

p.M246I

c.738G>A

2 papers

NM_000546.6

p.M246delFs

c.737delA

1 paper

NM_000546.6

p.N239_M246delFs

c.715_737del23

70 papers

NM_000546.6

p.M246R

c.737T>G

63 papers

NM_000546.6

p.M246T

c.737T>C

45 papers

NM_000546.6

p.M246K

c.737T>A

3 papers

NM_000546.6

p.M246delFs

c.736delT

2 papers

NM_000546.6

p.G245_M246del1

c.734_736delTGC

1 paper

NM_000546.6

p.G244_M246del0

c.731_736del6