Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

45 papers

NM_000546.6

p.M246K

c.737T>A

Surrounding Variants

70 papers

NM_000546.6

p.M246R

c.737T>G

63 papers

NM_000546.6

p.M246T

c.737T>C

3 papers

NM_000546.6

p.M246delFs

c.736delT

2 papers

NM_000546.6

p.G245_M246del1

c.734_736delTGC

1 paper

NM_000546.6

p.G244_M246del0

c.731_736del6

1 paper

NM_000546.6

p.G244_M246delFs

c.730_736del7

1 paper

NM_000546.6

p.S241_M246delFs

c.723_736del14

1 paper

NM_000546.6

p.S241_M246del0

c.722_736del15

1 paper

NM_000546.6

p.S240_M246del0

c.719_736del18

2 papers

NM_000546.6

p.N239_M246del0

c.716_736del21

146 papers

NM_000546.6

p.M246I

c.738G>T

1 paper

NM_000546.6

p.M246_N247insFs

c.738_739ins13