Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M243_G244del0

c.727_732del6

Surrounding Variants

327 papers

NM_000546.6

p.G245C

c.733G>T

1 paper

NM_000546.6

p.M243_G244ins0

c.727_732dup6

1 paper

NM_000546.6

p.G244_G245ins2

c.732_733ins6

1 paper

NM_000546.6

p.G245_M246insT

c.733_737ins3

1 paper

NM_000546.6

p.G245_M246insTG

c.733_737ins6

1 paper

NM_000546.6

p.G245insFs

c.733_734insA

87 papers

NM_000546.6

p.G245R

c.733G>C

1359 papers

NM_000546.6

p.G245S

c.733G>A

NM_001126115.2

p.G113S

c.337G>A

NM_001276760.3

p.G206S

c.616G>A

1 paper

NM_000546.6

p.S241_G244del0

c.721_732del12

1 paper

NM_000546.6

p.N239_G244del0

c.715_732del18

6 papers

NM_000546.6

p.G245fs

c.733_734fs

292 papers

NM_000546.6

p.G245V

c.734G>T