Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

96 papers

NM_000546.6

p.G244V

c.731G>T

Surrounding Variants

49 papers

NM_000546.6

p.G244A

c.731G>C

NM_001126115.2

p.G112A

c.335G>C

242 papers

NM_000546.6

p.G244D

c.731G>A

2 papers

NM_000546.6

p.G244delins

c.730_731delinsAA

2 papers

NM_000546.6

p.S241_G244del0

c.722_730del9

173 papers

NM_000546.6

p.G244C

c.730G>T

1 paper

NM_000546.6

p.G244_G245insAC

c.730_734ins6

37 papers

NM_000546.6

p.G244R

c.730G>C

221 papers

NM_000546.6

p.G244S

c.730G>A

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsTT

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsAT

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsAA

1 paper

NM_000546.6

p.M243del1

c.727_728delCAT