Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

221 papers

NM_000546.6

p.G244S

c.730G>A

Surrounding Variants

173 papers

NM_000546.6

p.G244C

c.730G>T

1 paper

NM_000546.6

p.G244_G245insAC

c.730_734ins6

37 papers

NM_000546.6

p.G244R

c.730G>C

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsTT

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsAT

1 paper

NM_000546.6

p.M243_G244delins

c.729_730delinsAA

1 paper

NM_000546.6

p.M243del1

c.727_728delCAT

1 paper

NM_000546.6

p.C242_M243delFs

c.725_728del4

1 paper

NM_000546.6

p.S240_M243del4

c.718_728del12

3 papers

NM_000546.6

p.C238_M243del0

c.712_729del18

1 paper

NM_000546.6

p.Y236_M243del8

c.706_728del24

9 papers

NM_000546.6

p.G244fs

c.730_731fs