Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

31 papers

NM_000546.6

p.C242*

c.726C>A

Surrounding Variants

2 papers

NM_000546.6

p.C242C

c.726C>T

36 papers

NM_000546.6

p.C242W

c.726C>G

63 papers

NM_000546.6

p.C242fs

c.724_725fs

1 paper

NM_000546.6

p.C242Fs

c.725_726delinsTFs

1 paper

NM_000546.6

p.C242delins

c.725_726delinsTT

2 papers

NM_000546.6

p.C242delFs

c.725delC

1 paper

NM_000546.6

p.C242delins

c.725_726delinsCA

1 paper

NM_000546.6

p.N239_C242delFs

c.715_725del11

1 paper

NM_000546.6

p.C238_C242delFs

c.712_725del14

244 papers

NM_000546.6

p.C242F

c.725G>T

NM_001126115.2

p.C110F

c.329G>T

1 paper

NM_000546.6

p.S241_C242ins0

c.722_724dupCCT

1 paper

NM_000546.6

p.S241_C242insFs

c.721_724dup4