Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

224 papers

NM_000546.6

p.C242Y

c.725G>A

Surrounding Variants

244 papers

NM_000546.6

p.C242F

c.725G>T

NM_001126115.2

p.C110F

c.329G>T

1 paper

NM_000546.6

p.S241_C242ins0

c.722_724dupCCT

1 paper

NM_000546.6

p.S241_C242insFs

c.721_724dup4

170 papers

NM_000546.6

p.C242S

c.725G>C

NM_001126115.2

p.C110S

c.329G>C

1 paper

NM_000546.6

p.C242delFs

c.724delA

1 paper

NM_000546.6

p.S241_C242delFs

c.723_724delAG

10 papers

NM_000546.6

p.S241del1

c.721_722delGGA

1 paper

NM_000546.6

p.N239_C242Fs

c.717_725delinsAFs

2 papers

NM_000546.6

p.N239_C242del0

c.716_724del9

1 paper

NM_000546.6

p.N239_C242delFs

c.715_724del10

1 paper

NM_000546.6

p.Y236_C242del0

c.707_724del18

3 papers

NM_000546.6

p.S241_C242insFs

c.723_724insC