Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

171 papers

NM_000546.6

p.C242S

c.724T>A

Surrounding Variants

3 papers

NM_000546.6

p.S241_C242insFs

c.723_724insC

58 papers

NM_000546.6

p.C242G

c.724T>G

66 papers

NM_000546.6

p.C242R

c.724T>C

74 papers

NM_000546.6

p.S241delFs

c.723delG

1 paper

NM_000546.6

p.S241delFs

c.722_723delGG

1 paper

NM_000546.6

p.N239_S241delFs

c.716_723del8

1 paper

NM_000546.6

p.N239_S241del0

c.715_723del9

42 papers

NM_000546.6

p.C242fs

c.724_725fs

244 papers

NM_000546.6

p.C242F

c.725G>T

NM_001126115.2

p.C110F

c.329G>T

1 paper

NM_000546.6

p.S241_C242ins0

c.722_724dupCCT

1 paper

NM_000546.6

p.S241_C242insFs

c.721_724dup4

170 papers

NM_000546.6

p.C242S

c.725G>C

NM_001126115.2

p.C110S

c.329G>C