Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

557 papers

NM_000546.6

p.S241F

c.722C>T

NM_001126115.2

p.S109F

c.326C>T

Surrounding Variants

197 papers

NM_000546.6

p.S241C

c.722C>G

4 papers

NM_001126118.2

p.S201insFs

c.603dupT

NM_000546.6

p.S241insFs

c.721dupT

149 papers

NM_000546.6

p.S241Y

c.722C>A

11 papers

NM_000546.6

p.S241delFs

c.721delA

1 paper

NM_000546.6

p.N239_S241del0

c.716_721del6

1 paper

NM_000546.6

p.C238_S241delFs

c.712_721del10

1 paper

NM_000546.6

p.S241_C242insA

c.721_725ins3

2 papers

NM_000546.6

p.S241_C242insAA

c.721_725ins6

2 papers

NM_000546.6

p.S241insFs

c.721_722insA

61 papers

NM_000546.6

p.S241A

c.721T>G

66 papers

NM_000546.6

p.S241P

c.721T>C

44 papers

NM_000546.6

p.S241T

c.721T>A