Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_000546.6

p.S241fs

c.721_722fs

Surrounding Variants

1 paper

NM_000546.6

p.S241_C242insA

c.721_725ins3

2 papers

NM_000546.6

p.S241_C242insAA

c.721_725ins6

2 papers

NM_000546.6

p.S241insFs

c.721_722insA

61 papers

NM_000546.6

p.S241A

c.721T>G

66 papers

NM_000546.6

p.S241P

c.721T>C

44 papers

NM_000546.6

p.S241T

c.721T>A

1 paper

NM_000546.6

p.S240del1

c.718_719delACT

4 papers

NM_000546.6

p.N239_S240del0

c.715_720del6

1 paper

NM_000546.6

p.N239_S240ins0

c.717_719dupCAG

1 paper

NM_000546.6

p.N239_S240insFs

c.717_718ins14

10 papers

NM_000546.6

p.S240fs

c.718_719fs

76 papers

NM_000546.6

p.S240R

c.720T>G