Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.N239_S240delFs

c.717_718delTG

Surrounding Variants

17 papers

NM_000546.6

p.S240I

c.719G>T

2 papers

NM_000546.6

p.S240insFs

c.718dupA

2 papers

NM_000546.6

p.N239_S240ins0

c.716_718dupACA

3 papers

NM_000546.6

p.N239_S240insFs

c.715_718dup4

38 papers

NM_000546.6

p.S240T

c.719G>C

79 papers

NM_000546.6

p.S240N

c.719G>A

1 paper

NM_000546.6

p.S240delFs

c.718delT

11 papers

NM_000546.6

p.N239del1

c.715_717delGTT

1 paper

NM_000546.6

p.N239_S240delFs

c.715_718del4

5 papers

NM_000546.6

p.M237_N239del3

c.709_716del9

1 paper

NM_000546.6

p.N239_S240ins0

c.717_719dupCAG

1 paper

NM_000546.6

p.N239_S240insFs

c.717_718ins14