Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C238_N239del2

c.712_716del6

Surrounding Variants

11 papers

NM_000546.6

p.S240fs

c.718_719fs

15 papers

NM_000546.6

p.S240C

c.718A>T

72 papers

NM_000546.6

p.S240G

c.718A>G

76 papers

NM_000546.6

p.S240R

c.718A>C

1 paper

NM_000546.6

p.S240insFs

c.718_719ins4

1 paper

NM_000546.6

p.S240Fs

c.718delinsTTATTACACATGTAFs

1 paper

NM_000546.6

p.S240ins6

c.718_719ins18

1 paper

NM_000546.6

p.N239_S240delins

c.716_718delinsGTT

1 paper

NM_000546.6

p.D228_N239del12

c.682_716del36

17 papers

NM_000546.6

p.S240I

c.719G>T

2 papers

NM_000546.6

p.S240insFs

c.718dupA

2 papers

NM_000546.6

p.N239_S240ins0

c.716_718dupACA