Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C238_N239insFs

c.714_715insTA

Surrounding Variants

18 papers

NM_000546.6

p.N239I

c.716A>T

147 papers

NM_000546.6

p.N239S

c.716A>G

33 papers

NM_000546.6

p.N239T

c.716A>C

3 papers

NM_000546.6

p.N239insFs

c.716_717insT

2 papers

NM_000546.6

p.C238_N239del1

c.713_715delTAC

1 paper

NM_000546.6

p.M237_N239del0

c.710_715del6

1 paper

NM_000546.6

p.I232_N239del0

c.695_715del21

3 papers

NM_000546.6

p.N239N

c.717C>T

27 papers

NM_000546.6

p.N239K

c.717C>G

1 paper

NM_000546.6

p.N239_S240insFs

c.717_718ins4

21 papers

NM_000546.6

p.N239fs

c.715_716fs

1 paper

NM_000546.6

p.N239_S240insFs

c.717_718ins4