Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

100 papers

NM_000546.6

p.N239Y

c.715A>T

Surrounding Variants

19 papers

NM_000546.6

p.N239fs

c.715_716fs

181 papers

NM_000546.6

p.N239D

c.715A>G

NM_001126115.2

p.N107D

c.319A>G

5 papers

NM_000546.6

p.N239H

c.715A>C

17 papers

NM_000546.6

p.C238_N239insFs

c.714_715insT

1 paper

NM_000546.6

p.C238_N239insFs

c.714_715ins4

1 paper

NM_000546.6

p.C238insFs

c.713_714dupGT

1 paper

NM_000546.6

p.N239_S240ins6

c.715_719ins18

1 paper

NM_000546.6

p.N239_S240ins11

c.715_719ins33

1 paper

NM_000546.6

p.C238_N239delins

c.714_715delinsGT

3 papers

NM_000546.6

p.C238delFs

c.714delA

5 papers

NM_000546.6

p.C238delFs

c.713_714delAC

2 papers

NM_000546.6

p.C238del1

c.712_714delACA