Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C238_N239insFs

c.714_715insGC

Surrounding Variants

2 papers

NM_000546.6

p.C238_N239insFs

c.714_715insGT

11 papers

NM_000546.6

p.C238fs

c.712_713fs

52 papers

NM_000546.6

p.C238W

c.714T>G

2 papers

NM_000546.6

p.C238C

c.714T>C

24 papers

NM_000546.6

p.C238*

c.714T>A

3 papers

NM_000546.6

p.C238delFs

c.713delC

1 paper

NM_000546.6

p.M237_C238del1

c.711_713delCAC

1 paper

NM_000546.6

p.N235_C238delFs

c.703_713del11

228 papers

NM_000546.6

p.C238F

c.713G>T

1 paper

NM_000546.6

p.C238insFs

c.712_713insTT

1 paper

NM_000546.6

p.M237_C238ins0

c.710_712dupTGT

130 papers

NM_000546.6

p.C238S

c.713G>C