Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.C238fs

c.712_713fs

Surrounding Variants

63 papers

NM_000546.6

p.C238G

c.712T>G

94 papers

NM_000546.6

p.C238R

c.712T>C

127 papers

NM_000546.6

p.C238S

c.712T>A

1 paper

NM_000546.6

p.M237delFs

c.711delC

1 paper

NM_000546.6

p.Y236_M237delFs

c.707_711del5

571 papers

NM_000546.6

p.M237I

c.711G>T

228 papers

NM_000546.6

p.C238F

c.713G>T

1 paper

NM_000546.6

p.C238insFs

c.712_713insTT

1 paper

NM_000546.6

p.M237_C238ins0

c.710_712dupTGT

7 papers

NM_000546.6

p.M237fs

c.709_710fs

564 papers

NM_000546.6

p.M237I

c.711G>C

130 papers

NM_000546.6

p.C238S

c.713G>C