Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

16 papers

NM_000546.6

p.M237R

c.710T>G

Surrounding Variants

1 paper

NM_000546.6

p.M237ins2

c.710_711ins6

1 paper

NM_000546.6

p.N235_M237ins1

c.704_709dup6

19 papers

NM_000546.6

p.M237T

c.710T>C

85 papers

NM_000546.6

p.M237K

c.710T>A

3 papers

NM_000546.6

p.M237delFs

c.709delT

2 papers

NM_000546.6

p.Y236_M237delFs

c.708_709delTG

9 papers

NM_000546.6

p.N235_M237del0

c.704_709del6

571 papers

NM_000546.6

p.M237I

c.711G>T

7 papers

NM_000546.6

p.M237fs

c.709_710fs

564 papers

NM_000546.6

p.M237I

c.711G>C

580 papers

NM_000546.6

p.M237I

c.711G>A

13 papers

NM_000546.6

p.M237fs

c.709_710fs