Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

68 papers

NM_000546.6

p.Y236H

c.706T>C

Surrounding Variants

1 paper

NM_000546.6

p.Y236_M237insAC

c.706_710ins6

74 papers

NM_000546.6

p.Y236D

c.706T>G

50 papers

NM_000546.6

p.Y236N

c.706T>A

3 papers

NM_000546.6

p.N235delFs

c.705delG

2 papers

NM_000546.6

p.N235del1

c.703_705delGTT

1 paper

NM_000546.6

p.H233_N235delFs

c.699_705del7

1 paper

NM_000546.6

p.I232_N235delFs

c.696_705del10

5 papers

NM_000546.6

p.Y236fs

c.706_707fs

3 papers

NM_000546.6

p.N235N

c.705C>T

15 papers

NM_000546.6

p.N235K

c.705C>G

5 papers

NM_000546.6

p.N235fs

c.703_704fs

15 papers

NM_000546.6

p.N235K

c.705C>A