Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

5 papers

NM_000546.6

p.N235fs

c.703_704fs

Surrounding Variants

3 papers

NM_000546.6

p.N235N

c.705C>T

15 papers

NM_000546.6

p.N235K

c.705C>G

15 papers

NM_000546.6

p.N235K

c.705C>A

3 papers

NM_000546.6

p.N235delFs

c.704delT

1 paper

NM_000546.6

p.N235Fs

c.703_705delinsTFs

1 paper

NM_000546.6

p.N235delFs

c.703_704delTT

1 paper

NM_000546.6

p.Y234_N235delFs

c.700_704del5

1 paper

NM_000546.6

p.Y236_M237insAC

c.706_710ins6

74 papers

NM_000546.6

p.Y236D

c.706T>G

68 papers

NM_000546.6

p.Y236H

c.706T>C

50 papers

NM_000546.6

p.Y236N

c.706T>A

3 papers

NM_000546.6

p.N235delFs

c.705delG