Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.Y234delFs

c.702delG

Surrounding Variants

5 papers

NM_000546.6

p.N235fs

c.703_704fs

12 papers

NM_000546.6

p.N235Y

c.703A>T

39 papers

NM_000546.6

p.N235D

c.703A>G

4 papers

NM_000546.6

p.N235H

c.703A>C

1 paper

NM_000546.6

p.Y234ins0

c.700_702dupTAC

1 paper

NM_000546.6

p.H233_Y234ins0

c.697_702dup6

1 paper

NM_000546.6

p.N235insFs

c.703_704ins13

13 papers

NM_000546.6

p.Y234del1

c.700_701delGTA

2 papers

NM_000546.6

p.T230_Y234delFs

c.690_702del13

1 paper

NM_000546.6

p.Y234Y

c.702C>T

58 papers

NM_000546.6

p.Y234*

c.702C>G

11 papers

NM_000546.6

p.Y234fs

c.700_701fs