Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.Y234F

c.701A>T

Surrounding Variants

412 papers

NM_000546.6

p.Y234C

c.701A>G

33 papers

NM_000546.6

p.Y234S

c.701A>C

2 papers

NM_000546.6

p.Y234insFs

c.700dupT

1 paper

NM_000546.6

p.Y234insFs

c.700_701ins4

1 paper

NM_000546.6

p.Y234delins

c.700_701delinsCG

1 paper

NM_000546.6

p.Y234Fs

c.700_701delinsCFs

2 papers

NM_000546.6

p.Y234delFs

c.700delA

1 paper

NM_000546.6

p.H233_Y234insFs

c.699_700ins7

1 paper

NM_000546.6

p.T231_H233insFs

c.693_699dup7

44 papers

NM_000546.6

p.Y234D

c.700T>G

173 papers

NM_000546.6

p.Y234H

c.700T>C

71 papers

NM_000546.6

p.Y234N

c.700T>A

NM_001126115.2

p.Y102N

c.304T>A