Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I232_H233delFs

c.695_698del4

Surrounding Variants

2 papers

NM_000546.6

p.H233H

c.699C>T

7 papers

NM_000546.6

p.H233Q

c.699C>G

7 papers

NM_000546.6

p.H233fs

c.697_698fs

6 papers

NM_000546.6

p.H233Q

c.699C>A

2 papers

NM_000546.6

p.H233Fs

c.698_699delinsTFs

1 paper

NM_000546.6

p.H233_Y234insFs

c.699_700ins7

1 paper

NM_000546.6

p.T231_H233insFs

c.693_699dup7

44 papers

NM_000546.6

p.Y234D

c.700T>G

173 papers

NM_000546.6

p.Y234H

c.700T>C

71 papers

NM_000546.6

p.Y234N

c.700T>A

NM_001126115.2

p.Y102N

c.304T>A

3 papers

NM_001126118.2

p.H194delFs

c.582delG

NM_000546.6

p.H233delFs

c.699delG

3 papers

NM_000546.6

p.H233delFs

c.697_698delTG