Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.I232insFs

c.694dupA

Surrounding Variants

1 paper

NM_000546.6

p.I232insFs

c.695_696insAT

1 paper

NM_000546.6

p.S227_I232ins2

c.680_694dup15

42 papers

NM_000546.6

p.I232S

c.695T>G

63 papers

NM_000546.6

p.I232T

c.695T>C

37 papers

NM_000546.6

p.I232N

c.695T>A

1 paper

NM_000546.6

p.I232delFs

c.694delT

6 papers

NM_000546.6

p.T231del1

c.691_692delGGT

1 paper

NM_000546.6

p.T230_I232delFs

c.690_694del5

8 papers

NM_000546.6

p.T230_T231del2

c.688_692del6

3 papers

NM_000546.6

p.I232I

c.696C>T

7 papers

NM_000546.6

p.I232M

c.696C>G

2 papers

NM_000546.6

p.I232insFs

c.695_696insT