Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.I232fs

c.694_695fs

Surrounding Variants

40 papers

NM_000546.6

p.I232F

c.694A>T

12 papers

NM_000546.6

p.I232V

c.694A>G

11 papers

NM_000546.6

p.I232L

c.694A>C

1 paper

NM_000546.6

p.T231insFs

c.693dupC

1 paper

NM_000546.6

p.I232insFs

c.694_695ins22

2 papers

NM_000546.6

p.T231delFs

c.693delG

1 paper

NM_000546.6

p.S227_T231del5

c.679_692del15

1 paper

NM_000546.6

p.G226_T231delFs

c.677_693del17

1 paper

NM_000546.6

p.V225_T231del0

c.673_693del21

1 paper

NM_000546.6

p.I232insFs

c.695_696insAT

1 paper

NM_000546.6

p.I232insFs

c.694dupA

1 paper

NM_000546.6

p.S227_I232ins2

c.680_694dup15