Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C229delFs

c.687delA

Surrounding Variants

4 papers

NM_000546.6

p.T230fs

c.688_689fs

5 papers

NM_000546.6

p.T230S

c.688A>T

14 papers

NM_000546.6

p.T230A

c.688A>G

20 papers

NM_000546.6

p.T230P

c.688A>C

1 paper

NM_000546.6

p.C229insFs

c.686_687dupGT

1 paper

NM_000546.6

p.T230insFs

c.688_689ins4

34 papers

NM_000546.6

p.C229delFs

c.686_687delAC

3 papers

NM_000546.6

p.C229del1

c.685_686delACA

1 paper

NM_000546.6

p.D228_C229del2

c.682_686del6

1 paper

NM_000546.6

p.G226_C229del0

c.676_687del12

1 paper

NM_000546.6

p.C229_T230insFs

c.687_688insC

31 papers

NM_000546.6

p.C229fs

c.685_686fs