Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

26 papers

NM_000546.6

p.C229Y

c.686G>A

Surrounding Variants

8 papers

NM_000546.6

p.C229F

c.686G>T

2 papers

NM_000546.6

p.C229insFs

c.685dupT

1 paper

NM_000546.6

p.C229Fs

c.686delinsACATGFs

1 paper

NM_000546.6

p.C229insFs

c.686_687insA

15 papers

NM_000546.6

p.C229S

c.686G>C

2 papers

NM_000546.6

p.C229delFs

c.685delA

1 paper

NM_000546.6

p.D228_C229delFs

c.684_685delAG

1 paper

NM_000546.6

p.C229_T230insFs

c.687_688insC

31 papers

NM_000546.6

p.C229fs

c.685_686fs

10 papers

NM_000546.6

p.C229G

c.685T>G

3 papers

NM_000546.6

p.C229W

c.687T>G

26 papers

NM_000546.6

p.C229R

c.685T>C