Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.D228insFs

c.682_683insTG

Surrounding Variants

11 papers

NM_000546.6

p.D228Y

c.682G>T

20 papers

NM_000546.6

p.S227_D228insFs

c.681_682insT

3 papers

NM_000546.6

p.S227_D228insFs

c.681_682insTT

13 papers

NM_000546.6

p.D228H

c.682G>C

23 papers

NM_000546.6

p.D228N

c.682G>A

3 papers

NM_000546.6

p.S227delFs

c.681delA

2 papers

NM_000546.6

p.S227_D228delins

c.681_682delinsCA

20 papers

NM_000546.6

p.D228fs

c.682_683fs

1 paper

NM_000546.6

p.S227insFs

c.680dupC

9 papers

NM_000546.6

p.S227fs

c.679_680fs

4 papers

NM_000546.6

p.S227S

c.681T>G

1 paper

NM_000546.6

p.S227S

c.681T>A