Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_000546.6

p.V225fs

c.673_674fs

Surrounding Variants

5 papers

NM_000546.6

p.V225F

c.673G>T

1 paper

NM_000546.6

p.V225insFs

c.673_674ins5

8 papers

NM_000546.6

p.V225L

c.673G>C

17 papers

NM_000546.6

p.V225I

c.673G>A

1 paper

NM_000546.6

p.V225insFs

c.673dupG

1 paper

NM_000546.6

p.V225insFs

c.674_675ins16

3 papers

NM_000546.6

p.V225G

c.674T>G

8 papers

NM_000546.6

p.V225A

c.674T>C

3 papers

NM_000546.6

p.V225D

c.674T>A

3 papers

NM_000546.6

p.V225delFs

c.673delC

44 papers

NM_000546.6

p.E224_V225Splc

c.673-1G>T

20 papers

NM_000546.6

p.E224_V225Splc

c.673-1G>C