Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E224_V225Splc

c.673-35C>T

Surrounding Variants

15 papers

NM_000546.6

p.E224_V225Splc

c.673-36G>C

3 papers

NM_000546.6

p.E224_V225Splc

c.673-37C>T

2 papers

NM_000546.6

p.E224_V225Splc

c.673-39G>A

1 paper

NM_000546.6

p.E224_V225Splc

c.673-25A>T

4 papers

NM_000546.6

p.E224_V225Splc

c.673-19G>A

1 paper

NM_000546.6

p.E224_V225Splc

c.673-18G>A

2 papers

NM_000546.6

p.E224_V225Splc

c.673-17C>T

1 paper

NM_000546.6

p.E224_V225Splc

c.673-54C>T

2 papers

NM_000546.6

p.E224_V225Splc

c.673-13T>C

1 paper

NM_000546.6

p.E224_V225Splc

c.673-12G>T

1 paper

NM_000546.6

p.E224_V225Splc

c.673-60G>C

1 paper

NM_000546.6

p.E224_V225Splc

c.673-9A>G