Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.E224_V225Splc

c.672+5G>T

Surrounding Variants

1 paper

NM_000546.6

p.E224_V225Splc

c.672+5G>A

1 paper

NM_000546.6

p.E224_V225Splc

c.672+6G>A

1 paper

NM_000546.6

p.E224_V225Splc

c.672+7T>G

1 paper

NM_000546.6

p.E224_V225Splc

c.672+7T>C

1 paper

NM_000546.6

p.E224_V225Splc

c.672+7T>A

1 paper

NM_000546.6

p.V218_E224del0

c.652_672del21

17 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>G

18 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>C

14 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>A

1 paper

NM_000546.6

p.E224delFs

c.672delC

1 paper

NM_000546.6

p.E224_V225Splc

c.672+9T>C

72 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>T