Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

18 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>C

Surrounding Variants

17 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>G

14 papers

NM_000546.6

p.E224_V225Splc

c.672+2T>A

1 paper

NM_000546.6

p.E224delFs

c.672delC

72 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>T

1 paper

NM_000546.6

p.E224insFs

c.671_672dupAG

11 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>C

78 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>A

1 paper

NM_000546.6

p.E224delFs

c.671_672delCT

1 paper

NM_000546.6

p.P223_E224del2

c.667_671del6

1 paper

NM_000546.6

p.Y220_E224delFs

c.659_672del14

1 paper

NM_000546.6

p.V218_E224del0

c.652_672del21

110 papers

NM_000546.6

p.E224D

c.672G>T