Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.E224delFs

c.671delT

Surrounding Variants

110 papers

NM_000546.6

p.E224D

c.672G>T

1 paper

NM_000546.6

p.E224_V225ins2

c.672_673ins6

8 papers

NM_000546.6

p.E224fs

c.670_671fs

1 paper

NM_000546.6

p.E224_V225insFs

c.672_673ins5

1 paper

NM_000546.6

p.E224_V225insFs

c.672_673insA

108 papers

NM_000546.6

p.E224D

c.672G>C

50 papers

NM_000546.6

p.E224E

c.672G>A

72 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>T

1 paper

NM_000546.6

p.E224insFs

c.671_672dupAG

11 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>C

78 papers

NM_000546.6

p.E224_V225Splc

c.672+1G>A

1 paper

NM_000546.6

p.E224delFs

c.671_672delCT