Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.E224_V225insA

c.670_674ins3

Surrounding Variants

43 papers

NM_000546.6

p.E224*

c.670G>T

6 papers

NM_000546.6

p.E224Q

c.670G>C

32 papers

NM_000546.6

p.E224K

c.670G>A

1 paper

NM_000546.6

p.P223delFs

c.669delA

1 paper

NM_000546.6

p.P223delFs

c.668_669delAG

1 paper

NM_000546.6

p.P222_E224Fs

c.665_670delinsTFs

1 paper

NM_000546.6

p.Y220_P223delFs

c.659_669del11

1 paper

NM_000546.6

p.P219_P223del5

c.655_668del15

1 paper

NM_000546.6

p.V218_P223delFs

c.653_669del17

1 paper

NM_000546.6

p.F212_P223del12

c.634_668del36

3 papers

NM_000546.6

p.E224fs

c.670_671fs

1 paper

NM_000546.6

p.P223insFs

c.668dupC