Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P223P

c.669T>A

Surrounding Variants

1 paper

NM_000546.6

p.P223insFs

c.668dupC

7 papers

NM_000546.6

p.P223fs

c.667_668fs

1 paper

NM_000546.6

p.P223_E224insFs

c.669_670insA

4 papers

NM_000546.6

p.P223delFs

c.668delG

1 paper

NM_000546.6

p.P223Fs

c.668_669delinsGFs

1 paper

NM_000546.6

p.P223delFs

c.667_668delGG

1 paper

NM_000546.6

p.P222_P223delFs

c.665_668del4

5 papers

NM_000546.6

p.P219_P223del0

c.657_668del12

43 papers

NM_000546.6

p.E224*

c.670G>T

3 papers

NM_000546.6

p.E224_V225insA

c.670_674ins3

6 papers

NM_000546.6

p.E224Q

c.670G>C

32 papers

NM_000546.6

p.E224K

c.670G>A