Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_000546.6

p.P223H

c.668C>A

Surrounding Variants

106 papers

NM_000546.6

p.P223L

c.668C>T

9 papers

NM_000546.6

p.P223R

c.668C>G

1 paper

NM_000546.6

p.E221_P223insFs

c.661_667dup7

1 paper

NM_000546.6

p.P223insFs

c.668_669insA

1 paper

NM_000546.6

p.P223delins

c.667_668delinsTT

1 paper

NM_000546.6

p.P222_P223delFs

c.666_667delGC

1 paper

NM_000546.6

p.E221_P223del0

c.662_667del6

1 paper

NM_000546.6

p.P223insFs

c.668dupC

7 papers

NM_000546.6

p.P223fs

c.667_668fs

1 paper

NM_000546.6

p.P223_E224insFs

c.669_670insA

1 paper

NM_000546.6

p.P223P

c.669T>A

4 papers

NM_000546.6

p.P223delFs

c.668delG