Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Y220_E221insFs

c.660_661insG

Surrounding Variants

16 papers

NM_000546.6

p.Y220fs

c.658_659fs

60 papers

NM_000546.6

p.Y220*

c.660T>G

56 papers

NM_000546.6

p.Y220*

c.660T>A

3 papers

NM_000546.6

p.Y220delFs

c.659delT

64 papers

NM_000546.6

p.E221*

c.661G>T

2 papers

NM_000546.6

p.Y220_E221insFs

c.660_661insT

3 papers

NM_000546.6

p.E221Q

c.661G>C

26 papers

NM_000546.6

p.E221K

c.661G>A

2 papers

NM_000546.6

p.Y220delFs

c.660delA

2 papers

NM_000546.6

p.Y220delFs

c.658_659delTA

2 papers

NM_000546.6

p.Y220del1

c.658_659delATA

4 papers

NM_000546.6

p.S215_Y220del0

c.643_660del18