Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P219P

c.657C>T

Surrounding Variants

1 paper

NM_000546.6

p.P219_Y220insFs

c.657_658insG

11 papers

NM_000546.6

p.P219fs

c.655_656fs

1 paper

NM_000546.6

p.P219_Y220insFs

c.657_658insTA

4 papers

NM_000546.6

p.P219P

c.657C>A

1 paper

NM_000546.6

p.P219delins

c.656_657delinsTT

1 paper

NM_000546.6

p.P219_Y220insFs

c.657_658insC

45 papers

NM_000546.6

p.Y220D

c.658T>G

133 papers

NM_000546.6

p.Y220H

c.658T>C

71 papers

NM_000546.6

p.Y220N

c.658T>A

6 papers

NM_000546.6

p.P219delFs

c.657delG

2 papers

NM_000546.6

p.P219delFs

c.655_656delGG

1 paper

NM_000546.6

p.P219del1

c.655_656delGGG