Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.V218delFs

c.654delC

Surrounding Variants

42 papers

NM_000546.6

p.P219S

c.655C>T

5 papers

NM_000546.6

p.P219A

c.655C>G

1 paper

NM_000546.6

p.V218insFs

c.654dupG

3 papers

NM_000546.6

p.V218ins0

c.652_654dupGTG

1 paper

NM_000546.6

p.V217_V218insFs

c.651_654dup4

1 paper

NM_000546.6

p.V217_V218insFs

c.650_654dup5

2 papers

NM_000546.6

p.V218_P219ins1

c.654_655insGTG

8 papers

NM_000546.6

p.P219T

c.655C>A

1 paper

NM_000546.6

p.V218delFs

c.653_654delCA

34 papers

NM_000546.6

p.V218del1

c.652_653delCAC

1 paper

NM_000546.6

p.V217_V218del2

c.649_653del6

1 paper

NM_000546.6

p.V216_V218del3

c.646_653del9