Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.V218delFs

c.652delC

Surrounding Variants

3 papers

NM_000546.6

p.V218insFs

c.652dupG

57 papers

NM_000546.6

p.V218G

c.653T>G

8 papers

NM_000546.6

p.V218A

c.653T>C

34 papers

NM_000546.6

p.V218E

c.653T>A

1 paper

NM_000546.6

p.V218delins

c.652_653delinsTG

11 papers

NM_000546.6

p.V218L

c.652G>T

2 papers

NM_000546.6

p.V218V

c.654G>T

8 papers

NM_000546.6

p.V218fs

c.652_653fs

2 papers

NM_000546.6

p.V218_P219insT

c.652_656ins3

1 paper

NM_000546.6

p.V218_P219insTT

c.652_656ins6

10 papers

NM_000546.6

p.V218L

c.652G>C

39 papers

NM_000546.6

p.V218M

c.652G>A